Atrial fibrillation (AF) is the most frequent arrhythmia and is associated with increased
morbidity and mortality. Current drugs for AF treatment have limited efficacy and a
substantial risk of proarrhythmic side effects, making novel drug development critical.
Emerging evidence suggests that abnormal intracellular calcium (Ca2+) signalling is a key
contributor to ectopic (triggered) electrical activity in human AF. Accordingly, atrial Ca2+-
handling abnormalities underlying ectopic activity may constitute novel mechanism-based …